1. 종양면역(tumor immunity), 면역체크포인트(immune checkpoint) 및 자가면역(autoimmunity)의 새로운 조절 기전 및 병인 기전 연구
: 종양면역에서 핵심적인 T 세포의 exhaustion 및 anergy 을 조절하는 새로운 분자기전을 연구팀에서 독자적으로 구축한 다양한 conditional knock-out (KO) 및 transgenic (Tg) 마우스를 활용하여 종양면역의 새로운 분자기전을 제시하고 진단 및 치료기술을 개발하고자 함.
2. 저분자화합물 및 항체를 이용한 혈액암, 림프종 및 자가면역질환의 치료기술 개발
: 본 연구팀에서 새롭게 발굴한 저분자화합물과 항체를 연구팀에서 구축한 다양한 종양 마우스 모델과 자가면역질환 마우스 모델에서 후보 치료물질에 의한 치료 효능의 검증, 작용 기전 및 독성 분석을 수행함.
3. 연구실에서 발굴한 Ssu72 (dual protein phosphatase)와 새로운 타입의 Pellino1 (ubiquitin E3 ligase)에 의한 질병의 새로운 발병 기전 및 치료의 분자표적에 대한 연구를 수행함
: 본 연구팀에서 구축한 다양한 종류의 conventional Tg, inducible Tg, conditional Tg mice 그리고 KO과 conditional KO mice을 이용하여 Ssu72와 Pellino 1 각각의 gain-of-function과 loss-of-function에 의한 질병화의 새로운 분자기전 및 치료기술에 대해서 연구함. 연구팀에서는 15종류 이상의 마우스를 활용하여 다양한 종류의 T 세포(CD4+, CD8+, Treg 및 Th17 cells), B 세포, microphage, adipocyte, hepatocyte, stem cell, keratinocyte, oval cell 등의 새로운 세포기능 및 관련된 질병에 대해서 연구함.
학력
(Ph.D.) University of Glasgow / National Institute for Medical Research, Institute of Biomedical and Life Science
약력/경력
(Post-doctoral Fellow) Harvard Medical School, Department of Cell Biology
(Research Professor) POSTECH, Division of Moelcular Life Science
(Senior Research Associate) National Cancer Center, Research Institute
(Professor) Samsung Advanved Institute for Health Sciences and Technology
(Professor) Sungkyunkwan University School of Medicine, Department of Biochemistry and Molecular Biology
학술지 논문
(2022)
Mammalian Ssu72 phosphatase preferentially considers tissue-specific actively transcribed gene expression by regulating RNA Pol II transcription.
THERANOSTICS.
12,
1
(2021)
Ssu72-HNF4 alpha signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma.
CELL DEATH AND DIFFERENTIATION.
29,
3
(2021)
Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
118,
35
(2021)
Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells.
CELLULAR & MOLECULAR IMMUNOLOGY.
18,
6
(2019)
Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks.
NATURE COMMUNICATIONS.
10,
1577
(2019)
De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.
NUCLEIC ACIDS RESEARCH.
47,
12
(2018)
The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.
NATURE COMMUNICATIONS.
9,
3843
(2016)
Pellino-1 promotes lung carcinogenesis via the stabilization of Slug and Snail through K63-mediated polyubiquitination.
CELL DEATH AND DIFFERENTIATION.
24,
3
(2016)
Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase.
HEPATOLOGY.
63,
1
(2015)
The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.
NATURE COMMUNICATIONS.
6,
(2014)
Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination.
JOURNAL OF CLINICAL INVESTIGATION.
124,
11
(2014)
Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients.
NATURE COMMUNICATIONS.
5,
5317
(2014)
The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.
NATURE COMMUNICATIONS.
5,
(2013)
Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion.
NATURE COMMUNICATIONS.
4,
2631
(2012)
Roles of 14-3-3η in mitotic progression and its potential use as a therapeutic target for cancers.
ONCOGENE.
31,
23
(2011)
Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.
CELL DEATH AND DIFFERENTIATION.
18,
10
(2010)
The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion.
EMBO JOURNAL.
29,
(2009)
Functional interaction between BubR1 and securin in an APCCdc20-independent manner.
CANCER RESEARCH.
69,
1
(2008)
Mitotic Catastrophe is the Predominant Response to Histone Acetyltransferase Depletion. Cell Death and Differentiation.
CELL DEATH AND DIFFERENTIATION.
16,
특허/프로그램
Pellino (PELI) 유비퀴틴 접합효소에 의한 중증 건선(Psoriasis)의 새로운 분자표적 발명및 질환동물모델 발굴과 이를 활용한 약제의 개과 평가 방법.
10-2017-0082620.
20191010.
대한민국
Ssu72을 유효성분으로 포함하는 자가면역질환 예방 또는 치료용 조성물.
10-2016-0038934 .
20171124.
대한민국
림프종 진단 또는 예후 마커로서 Ｐｅｌｌｉｎｏ 1{Pellino 1 as a marker for the diagnosis or prognosis of lymphoma}.
PA100141KR.
20120907.
PCT
사이클린 의존성 인산화효소의 발현 또는 활성 억제제의 존부를 조절하여 성체 줄기세포와 신경세포 간의 분화를 유도하는 방법 {Method of inducing differentiation of adult stem cells into neural cells by controlling an expression or activity of cyclin-dependent kinases}.
PA100042KR1.
20120813.
PCT
수상/공훈
KBS 생로병사 및 YTN, 중앙일보, 한국일보 등의 언론에 연구팀의 연구성과 70회 이상 보도됨
학술회의논문
(2019)
Therapeutic intervention of receptor-mediated ubiquitination signaling
in tumor immunity and autoimmunity.
The 71st Annual Meeting of Korean Society of Pharmacology.
대한민국
(2019)
Ubiquitination of BCR-mediated signaling protein by Pellino1 in B cell development.
17th International Congress of Immunology.
중국
(2019)
Hypophosphorylation of T cell receptor signaling in regulating the differentiation of peripherally derived regulatory T cells.
World Immune Regulation Meeting XIII.
스위스
(2018)
Ssu72 phosphatase regulates tissue-resident macrophage function.
2018 European Congress of Immunology.
네덜란드
(2018)
Regulation of lipid metabolism by Ssu72 phosphatase.
Federation of American Societies for Experimental Biology.
미국
(2018)
BCR signaling responsive ubiquitination by Pellino 1 in B cell development.
B Cells: Mechanisms in Immunity and Autoimmunity.
독일
(2018)
Ssu72 phosphatase regulates thermogenesis through macrophage polarization.
American Association of Immunology.
미국
(2017)
Signal responsive polyubiquitination monitoring for DNA damage response and pathogenesis.
방사선생명과학회 추계학술대회.
대한민국
(2017)
A systemic E3 ubiquitin ligase signaling cascade of tumorigenesis and anti-tumor immunity.
암미세환경연구 심포지움.
대한민국
(2017)
Development of lymphoid tumors by Pellino 1-BubR1 signaling axis which deregulate mitotic spindle checkpoint.
Cold Spring Harbor Symposium.
미국
(2016)
Dual Protein Phosphatase Ssu72 in Cellular Lineage and Pathogenesis.
2017 Korean Society of Molecular Cell Biology Cell Cycle Round Table.
대한민국
(2016)
2016 Internation Conference of the Korean Society for Molecular Cellular Biology
'Symposium 07. Cell Ccyle Control in Diseases' Session Organizor & Chair.
2016 Internation Conference of the Korean Society for Molecular Cellular Biology'Symposium 07. Cell Ccyle Control in Diseases' Session Organizor & Chair.
대한민국
(2016)
Pellino 1 E3 Ubiquitin Ligase Affecting Cell Cycle Control and Pathogenesis.
2016 KSMCB Cell Cycle Symposium.
대한민국
(2016)
Potential Coupling of Ssu72 Phosphatase-Mediated Cell Cycle Control with T Cell Immunity.
2016 Korean Society of Molecular Cell Biology Cell Cycle Symposium.
대한민국
(2015)
2015 KSMCB Cell Cycle Symposium에서 'Ssu72 Protein Phosphatas in Cell Cycle-Related Pathogenesis'주제로 초청 강연함.
2015 KSMCB Cell Cycle Round Table Symposium.
대한민국
(2015)
2015 East Asia Joint Symposium 에서 'SSU72 function as a gatekeeper monitoring for chromosome integrity' 주제로 발표함.
2015 East Asia Joint Symposium.
일본
(2015)
The 74th Annual Meeting of the Japanese Cancer Association의 International Session 1 'Molecular ground for chromosomal instability'에서 'The Role of Ssu72 Protein Phosphatase in Regulating Chromosome Cohesion and Ploidy'주제로 강연함.
The 74th Annual Meeting of the Japanese Cancer Association (일본암학회 학술대회).
일본
(2015)
2015 Internation Conference of Korean Society of Molecular and Cell Biology 심포지움에서 'BEX protein attenuates the mitotic checkpoint and induces preneoplastic aneuploidy'이란 내용의 연구결과를 초록으로 발표함.
2015 Internation Conference of Korean Society of Molecular and Cell Biology.
대한민국
(2015)
2015 International Conference of the KSMCB 'Functional role of Pellino 1 in lung cancer tumorigenesis' 연구결과에 대해서 발표함.
2015 International Conference of the KSMCB.
대한민국
(2015)
2015 International Conference of the KSMCB 'SSU72 function as a gatekeeper monitoring for chromosome integrity'이라는 연구주제에 대해서 초록을 발표함.
2015 International Conference of the KSMCB.
대한민국
